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Bradykinin and inflammatory pain. Trends Neurosci 1993; 16: 99 – 104 6 Han ED, MacFarlane RC, Mulligan AN, Scafidi J, Davis AE, 3rd. Increased vascular permeability in C1 inhibitor-deficient mice mediated by the bradykinin type 2 receptor. J Clin Invest 2002; 109: 1057 – 1063 7 Kaplan AP, Joseph K, Shibayama Y, Reddigari S, Ghebrehiwet B, Silverberg M. The intrinsic coagulation/ kinin-forming cascade: assembly in plasma and cell surfaces in inflammation. Adv Immunol 1997; 66: 225 – 272 8 Mandle RJ, Colman RW, Kaplan AP.
Soluble ACE is a posttranslationally modified form of the membrane-bound enzyme and is generated via proteolytical cleavage of the ACE C-terminus. The proteolytic cleavage occurs extracellularly in the juxtamembrane “stalk” region of ACE . However, the secretase responsible for the protoeolysis has not yet been identified.
Lancet 1998; 351: 1693 – 1697 2 Nussberger J, Cugno M, Cicardi M. Bradykinin-mediated angioedema. N Engl J Med 2002; 347: 621 – 622 3 Bas M, Kojda G, Bier H, Hoffmann TK. Durch ACEHemmer induziertes Angioödem des Kopf-Hals-Bereichs. Eine Frage der Zeit? HNO 2004; 52: 886 – 890. 4 Bas M, Kojda G. Angioödem nach Einnahme von Irbesartan [Angioedema induced by irbesartan]. Apothekenmagazin 2005; 23: 254 – 255 5 Hellebrand MC, Kojda G, Hoffmann TK, Bas M. [Angioedema due to ACE inhibitors and AT(1) receptor antagonists].
Angioedema congress book : 3 tables by Murat Bas